Prognostic factors for metachronous contralateral breast


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2016-09-21 Aim: To identify differences in the incidence of contralateral breast cancer between patients with a primary tumour diagnosis of invasive ductal carcinoma (IDC) and those with a diagnosis of invasive lobular carcinoma (ILC). Materials and methods: Data from two large cancer registries (registry A & B) the Northern and Yorkshire Cancer Registry Information Service (NYCRIS) and the West Midlands Background: Women with ductal carcinoma in situ (DCIS) are increasingly choosing bilateral mastectomy. We sought to quantify rates of contralateral breast cancer (CBC) and ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery (BCS) for DCIS, and to … 5 rows 2015-08-05 2016-02-01 Breast cancer survivors are at risk for contralateral breast cancer (CBC), with the consequent burden of further treatment and potentially less favorable prognosis. We aimed to develop and validate a CBC risk prediction model and evaluate its applicability for clinical decision-making. We included data of 132,756 invasive non-metastatic breast cancer patients from 20 studies with 4682 CBC A contralateral breast cancer is a new cancer that occurs in the breast opposite to the one you already had breast cancer in. A contralateral breast cancer is not considered a recurring cancer.

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Radiation Epidemiology Branch (REB) investigators and collaborators from the Kaiser health maintenance organization have developed a retrospective cohort of about 7,000 breast cancer patients diagnosed since 1991. Contralateral breast cancer: incidence according to ductal or lobular phenotype of the primary There is no apparent increase in risk of developing a contralateral breast cancer according to the primary cancer histology either IDC or ILC. Standard mammographic follow-up does not need to take account of original tumour pathology. The most common of these second cancers is contralateral breast cancer (CBC), which is estimated to occur at a rate of 0.5% per year (3–6). CBCs are often more difficult to treat than the original cancer because of more resistant biology and inability to reuse previous effective therapy due to dose-limiting toxicities (6–8). Contralateral disease was defined as invasive malignancy or ductal carcinoma in situ (DCIS) in the other breast diagnosed either at the same time or at any point following the diagnosis of the original index tumour during the study period. Some more recent studies have suggested that contralateral breast cancer is more frequent amongst those with ILC than in patients with IDC (20.9% versus 11.2%; p<0.0001) 1; however, others found no significant difference in rates of contralateral breast cancer with ILC (11.9%) compared with IDC (11.3%; p=0.86).

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1999-10-01 Increasing breast density had a dose-dependent effect on the risk of contralateral breast cancer. Relative to 'almost entirely fat' category of breast density, the adjusted odds ratios (and p values) in the multivariate analysis for 'scattered density,' 'heterogeneously dense,' and 'extremely dense' categories were 1.65 (0.036), 2.10 (0.002), and 2.32 (0.001), respectively. 2020-04-17 We undertook a double-blind, randomised, placebo-controlled trial to compare anastrozole with tamoxifen for the prevention of locoregional and contralateral breast cancer. Participants were women aged 40–70 years, postmenopausal, and had DCIS diagnosed within 6 months before randomisation.

Contralateral breast cancer

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Contralateral breast cancer

Find evidence-based information on breast cancer treatment, causes … 2021-03-31 2020-08-24 2016-09-21 · Contralateral breast cancer (CBC) is the most common second primary cancer in patients diagnosed with breast cancer.

Contralateral breast cancer

This process is experimental and the keywords may be updated as the learning algorithm improves. The reasons for the high risk of contralateral breast cancer are not understood, although polygenic mechanisms have been suggested to be involved. The nationwide Swedish Family-Cancer Database was used to examine the interaction of the risks for contralateral and familial cancer. Relative risks were separately determined for contralateral and familial breast cancers, and these were tested for contralateral breast cancer.
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We sought to quantify rates of contralateral breast cancer (CBC) and ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery (BCS) for DCIS, and to compare risk factors for CBC and IBTR. contralateral breast cancer (CBC); a new primary cancer in the opposite breast. With this cancer added to the first, these women have significantly worse prognosis compared to women with only onebreast cancer. The incidence of breast cancer is very high and as the mortality after breast cancer keeps improving,CBC will be of increasing importance.

CBCs are often more difficult to treat than the original cancer because of more resistant biology and inability to reuse previous effective therapy due to dose-limiting toxicities (6–8).
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Metastasismönster hos kvinnor med metakron kontralateral

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2014-02-11 · In this analysis, after a diagnosis of breast cancer in the contralateral breast, the mortality rate was increased twofold (hazard ratio 2.17, 95% confidence interval 1.26 to 3.75; P=0.005). Of the 20 women who died between years 10 and 20, 11 (55%) had experienced a second primary cancer (three ipsilateral, nine contralateral). 2021-04-10 · A few cases of NF1 patients with contralateral breast cancer have been identified in the literature, and our case highlights an NF1 patient who developed contralateral breast cancer nearly four decades after her initial breast cancer diagnosis.